NEWSLETTER OF H2020 - INFRAIA-02-2020 "PANACEA" |
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Editor-in-chief: Raphaële Coulon |
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| | Spring hands-on workshop Lyon, France - May 19th-23rd 2025
The PANACEA Spring Hands-on Workshop concluded successfully on Friday 23rd of May, marking the end of a dynamic and enriching week dedicated to advanced training in pNMR, DNP and related spectroscopic techniques.
The workshop brought together 30 participants, 7 expert speakers, and 9 supervisors from accross Europe and beyond. This intensive program offered a balanced mix of theoretical lectures, experimental sessions, and collaborative discussions.
Read more... |
| PANACEA key numbers- 1650 access days
- 27 spectrometers
- > 200 chemistry-related projects
| - 4 user meetings
- 3 hands-on trainings
- 1 NMR summer School
| - 3 industry-targeted workshops
- 32 taster days for industrials
- 8 summer fellowships for students
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Exciting Joint Research Activity Publication- Advances of 1H–19F CP-MAS-DNP for pharmeceutical formulations
| Pharmaceutical research is an excellent area where solid-state NMR has a large societal impact.
The 2025 PANACEA publication showcases the integration of innovative probe technology with the study of advanced pharmaceutical formulations. It introduces a novel dynamic nuclear polarization (DNP) probe leveraging the ^19F nucleus, commonly present in commercial active pharmaceutical ingredients (APIs), to enable detailed analysis of drug formulations.
The study presents results for a commercially relevant API in both its pure powder form and its formulation within loaded polymeric nanoparticles. By transferring hyperpolarization from ^1H to ^19F nuclei using cross-polarization, and taking advantage of the faster build-up times of DNP-enhanced ^1H polarization, the approach allows for reduced recycle delays and significantly improved sensitivity and efficiency. The unique triple-channel, low-temperature, solid-state DNP-NMR probe—with independent radiofrequency channels for ^1H and ^19F—permits separate pulsing and superior acquisition of fluorine spectra in terms of sensitivity and resolution.
| M. Šoltésová, A. C. Pinon, F. Aussenac, J. Schlagnitweit, C. Reiter, A. Purea, R. Melzi e, F. Engelke, D. Martin, S. Krambeck, A. Biscans, E. Kay, L. Emsley and S. Schantz, 1H–19F cross-polarization magic angle spinning dynamic nuclear polarization NMR investigation of advanced pharmaceutical formulations J. Magn. Reson. 371, 107827, 2025. |
| | Meet the PANACEA team at EUROMAR 2025!Oulu, Finland - July 6th-10th 2025
Find out the latest developments in the Joint Research Activities, learn more about how you get access to 27 uniquely-equipped solid-state NMR instruments through our PANACEA Transnational Access scheme and ask any questions to our experts scientists.
The PANACEA booth will be located in the exhibition space at the main congress venue as part of one of the events' sponsors, come and meet us at booth 1.
See you at EUROMAR 2025 in Oulu! |
| | Summer Research Visits to MagLab! Tallahassee, Florida - August,18th-29th 2025 The PANACEA consortium is excited to announce a summer research visit opportunity at the National High Magnetic Field Laboratory (MagLab) in tallahassee, Florida.
This exchange scheme is open to 8 motivated undergraduate, Master or PhD students with a keen interest in conducting supervised research in solid-state NMR and MAS-DNP-NMR.
These fully funded summer research visits provide a unique opportunity for highly motivated young researchers and students at different career stages, backgrounds and geographical origins to visit the MagLab and be part of an internationally leading research environment.
Read more... |
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