The uniqueness of this triple-channel low temperature solid-state DNP probe lies in separate radiofrequency channels for 1H and 19F Larmor frequency, thus enabling independent pulsing on both proton and fluorine nuclei. This allows for acquiring fluorine spectra with much better sensitivity and resolution. The above mentioned features make this newly developed probe an indispensable tool for investigating pharmaceutical formulations, which often contain fluorine. Combined with the dynamic nuclear polarization (DNP) enhancement of the NMR signal, the future prospects are to perform in-cell detection of pharmaceuticals upon natural uptake.
